The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2017
Filed:
Feb. 21, 2014
Applicant:
Joslin Diabetes Center, Inc., Boston, MA (US);
Inventors:
Rohit N. Kulkarni, Chestnut Hill, MA (US);
Abdelfattah El Ouaamari, Boston, MA (US);
Daniel Margerie, Frankfurt am Main, DE;
Matthias Lohmann, Frankfurt am Main, DE;
Jean Claude Guillemot, Espanes, FR;
Denis Loyaux, Belbeze, FR;
Assignee:
Joslin Diabetes Center, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/81 (2006.01); A61K 38/17 (2006.01); A61K 38/55 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1709 (2013.01); A61K 38/55 (2013.01);
Abstract
Compositions and methods of use are provided for improving β cell function and promoting pancreatic β cell proliferation in vitro, in vivo and ex vivo. The active agents of the pending invention comprise Serpin family peptides (e.g., SerpinB1), functional and structural analogs of Serpin family peptides and nucleic acids encoding Serpin family peptides, as well as active fragments thereof.