The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 2017
Filed:
Dec. 21, 2013
Applicant:
Advanced Cell Technology, Inc., Marlborough, MA (US);
Inventors:
Assignee:
Astellas Institute for Regenerative Medicine, Marlborough, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/19 (2015.01); C12N 5/078 (2010.01);
U.S. Cl.
CPC ...
A61K 35/19 (2013.01); C12N 5/0644 (2013.01); C12N 2501/04 (2013.01); C12N 2501/20 (2013.01); C12N 2501/2306 (2013.01); C12N 2501/2309 (2013.01); C12N 2501/2311 (2013.01); C12N 2501/30 (2013.01); C12N 2501/40 (2013.01); C12N 2501/727 (2013.01); C12N 2501/734 (2013.01); C12N 2501/91 (2013.01); C12N 2506/11 (2013.01);
Abstract
Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.