Motion sensitized and motion suppressed imaging using dante prepared pulse trains

Abstract

Systems and methods for motion sensitized and motion suppressed quantitative imaging of a subject are provided as a train of interlaced radio frequency (RF) and magnetic field gradient pulses. Non-selective Delay Alternating with Nutation for Tailored Excitation (DANTE) pulse trains may be used in combination with gradient pulses and short repetition times as motion-sensitive preparation modules. In one or more embodiments, the systems and methods may use a train of low flip angle radio frequency (RF) pulses in combination with a blipped field gradient pulse between each RF pulse, repeated regularly. While the longitudinal magnetization of static tissue is mostly preserved, moving spins are largely (or fully) suppressed since they fail to establish transverse steady state due to a spoiling effect caused by flow along the applied gradient. The present systems and methods can be incorporated into any existing imaging readout for applications in vessel wall imaging, angiography, high resolution structural MRI, and also functional MRI.