The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 12, 2017

Filed:

Sep. 06, 2014
Applicant:

Cyvek, Inc., Wallingford, CT (US);

Inventors:

Martin A. Putnam, Cheshire, CT (US);

John H. Leamon, Stonington, CT (US);

Jeffrey T. Branciforte, Hartford, CT (US);

Charles O. Stanwood, Durham, CT (US);

Assignee:

CyVek, Inc., Wallingford, CT (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/543 (2006.01); B01L 3/00 (2006.01); G01N 21/05 (2006.01); G01N 21/64 (2006.01); G01N 21/03 (2006.01); G01N 35/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/54366 (2013.01); B01L 3/502707 (2013.01); B01L 3/502723 (2013.01); B01L 3/502738 (2013.01); B01L 3/502761 (2013.01); G01N 21/05 (2013.01); G01N 21/645 (2013.01); B01L 2200/027 (2013.01); B01L 2200/0689 (2013.01); B01L 2200/16 (2013.01); B01L 2300/0636 (2013.01); B01L 2300/087 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/0887 (2013.01); B01L 2300/123 (2013.01); B01L 2300/168 (2013.01); B01L 2400/0481 (2013.01); B01L 2400/0638 (2013.01); B01L 2400/0655 (2013.01); B01L 2400/086 (2013.01); G01N 2021/0346 (2013.01); G01N 2021/058 (2013.01); G01N 2035/00158 (2013.01); Y10T 29/494 (2015.01);
Abstract

A microfluidic device comprising a microfluidic channel network sealed on one side by a membrane sheet, the sheet having PDMS defining at least the surface sealing the channel, the membrane sheet on its opposite side sealing one side of a pneumatic channel, the pneumatic channel arranged to enable pneumatic deflection of a deflectable portion of the membrane sheet into contact with an opposed surface to control flow in a channel of the network, the membrane sheet confining in a channel of the network at least one micro-particle, micro-length tube or glass nano reactor, functionalized with a capture agent, that has been inserted into that channel. A microfluidic device having a microfluidic channel containing at least two micro-particles, micro-length tubes or glass nano reactors, one functionalized with nucleic acid and another with antibody or antigen. A microfluidic device having a microfluidic channel containing at least one micro-length tube or glass nano reactor functionalized to capture nucleic acid, the device constructed to enable recovery of the nucleic acid captured by the device.


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