The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 12, 2017

Filed:

Jan. 31, 2014
Applicants:

Manikkam Suthanthiran, Scarsdale, NY (US);

Ruchuang Ding, Beechurst, NY (US);

Joseph E. Schwartz, East Setauket, NY (US);

Abraham Shaked, Wynnewood, PA (US);

Inventors:

Manikkam Suthanthiran, Scarsdale, NY (US);

Ruchuang Ding, Beechurst, NY (US);

Joseph E. Schwartz, East Setauket, NY (US);

Abraham Shaked, Wynnewood, PA (US);

Assignees:

Cornell University, Ithaca, NY (US);

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/48 (2006.01); G01N 31/00 (2006.01); G06G 7/48 (2006.01); G06G 7/58 (2006.01); C12Q 1/68 (2006.01); A61K 31/365 (2006.01); A61K 31/56 (2006.01); A61K 31/436 (2006.01); A61K 31/52 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); A61K 31/365 (2013.01); A61K 31/436 (2013.01); A61K 31/52 (2013.01); A61K 31/56 (2013.01); C12Q 2600/158 (2013.01);
Abstract

Methods for prevention and treatment of kidney transplant rejection are described that involve determination, analysis and computation of a 3-gene molecular signature of levels of specific RNAs (IP-10 mRNA, CD3ε mRNA, and 18S rRNA) in urinary sample cells. The methods and devices described herein are diagnostic and prognostic of acute cellular rejection in kidney allografts.


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