The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2017
Filed:
Jun. 17, 2011
Puma, a pro-apoptotic gene, as a novel molecular biomarker for tnfα-induced human islet damage
Yoko Mullen, Sherman Oaks, CA (US);
Masato Mitsuhashi, Irvine, CA (US);
Keiko Omori, Pasadena, CA (US);
Yoko Mullen, Sherman Oaks, CA (US);
Masato Mitsuhashi, Irvine, CA (US);
Keiko Omori, Pasadena, CA (US);
City of Hope, Duarte, CA (US);
Hitachi Chemical Research Center, Inc., Irvine, CA (US);
Hitachi Chemical Co., Ltd., Tokyo, JP;
Abstract
p53-upregulated modulator of apoptosis (PUMA) is a biomarker associated with islet cell health. If PUMA is low, islet cells are typically healthy. If PUMA is high, islet cells are typically unhealthy or dying. PUMA may be measured by either measuring its nucleic or amino acid. PUMA mRNA may be induced by TNF-α stimulation in a time- and dose-dependent manner and β cell apoptosis is induced through a mitochondrial pathway. TNF-α significantly inhibited glucose-induced preproinsulin precursor mRNA synthesis. Such β cell stress signaling in human islets indicates overall state of islet health and, ultimately, the risk of onset and/or degree of severity of both type 1 and type 2 diabetes mellitus.