The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 12, 2017

Filed:

Jul. 12, 2013
Applicant:

Baylor College of Medicine, Houston, TX (US);

Inventors:

Matthew L. Anderson, Houston, TX (US);

Claire Mach, Houston, TX (US);

Preethi Gunaratne, Houston, TX (US);

Assignees:

Baylor College of Medicine, Houston, TX (US);

University of Houston, Houston, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61K 45/06 (2006.01); A61K 31/7088 (2006.01); A61K 33/24 (2006.01); C07H 21/04 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1135 (2013.01); A61K 31/7088 (2013.01); A61K 33/24 (2013.01); A61K 45/06 (2013.01); C12N 15/113 (2013.01); A61K 9/0019 (2013.01); C12N 2310/141 (2013.01); C12N 2320/11 (2013.01); C12N 2320/31 (2013.01); C12N 2330/10 (2013.01);
Abstract

The present invention concerns methods and compositions regarding one or more microRNAs or variants thereof that are provided to an individual for a variety of medical treatments, including sensitization to cancer therapy or prevention of a cancer to become sensitized to a cancer therapy. In specific embodiments, the microRNAs include miR-520a (including at least miR-520a-3p and miR-520-5p), miR-520g, miR-520h, and functional variants thereof. In some embodiments, the cancer is ovarian cancer, and in particular embodiments, the cancer therapy is platinum-based chemotherapy.


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