The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 12, 2017

Filed:

Apr. 09, 2012
Applicants:

Kiyotoshi Sekiguchi, Osaka, JP;

Yukimasa Taniguchi, Osaka, JP;

Masato Nakagawa, Kyoto, JP;

Inventors:

Kiyotoshi Sekiguchi, Osaka, JP;

Yukimasa Taniguchi, Osaka, JP;

Masato Nakagawa, Kyoto, JP;

Assignees:

OSAKA UNIVERSITY, Osaka, JP;

KYOTO UNIVERSITY, Kyoto, JP;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/074 (2010.01); C07K 14/78 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0696 (2013.01); C07K 14/78 (2013.01); C07K 2319/02 (2013.01); C07K 2319/21 (2013.01); C07K 2319/42 (2013.01); C07K 2319/43 (2013.01);
Abstract

Provided are a modified laminin having a cell-growth regulatory molecule bound to at least one site selected from the α chain N-terminus, the α chain C-terminus, the β chain N-terminus and the γ chain N-terminus of laminin or a heterotrimeric laminin fragment, a method for culturing cells in the presence of the modified laminin, a method for establishing iPS cells in the presence of the modified laminin, and a culture substrate coated with the modified laminin. Human stem cells cultured in a xeno-free environment with the use of the modified laminin of the present invention can be provided as highly safe human stem cells applicable to regenerative medicine.


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