The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2017
Filed:
Nov. 14, 2013
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Dipali Deshpande, White Plains, NY (US);
Gang Chen, Yorktown Heights, NY (US);
Darya Burakov, Yonkers, NY (US);
James Fandl, LaGrangeville, NY (US);
Thomas Aldrich, Yorktown Heights, NY (US);
Vishal Kamat, Bergenfield, NJ (US);
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
Recombinant cell surface capture proteins and detection molecules that are useful for isolating and detecting cells that produce a secreted heterodimeric protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain are provided. Recombinant cell surface capture proteins and detection molecules that isolate and detect bispecific antibodies are also provided. The invention also provides recombinant antigen-binding proteins that are capable of recognizing and binding to proteins of interest that contain a CH3 domain and/or a modified CH3 domain, such as a CH3 domain with or without amino acid substitutions at H95 and Y96 (IMGT).