The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 12, 2017

Filed:

Jan. 08, 2016
Applicant:

Hoffmann-la Roche Inc., Little Falls, NJ (US);

Inventors:

Lei Guo, Shanghai, CN;

Taishan Hu, Shanghai, CN;

Yimin Hu, Shanghai, CN;

Buelent Kocer, Basel, CH;

Buyu Kou, Shanghai, CN;

Gangqin Li, Shanghai, CN;

Xianfeng Lin, Shanghai, CN;

Haixia Liu, Shanghai, CN;

Hong Shen, Shanghai, CN;

Houguang Shi, Shanghai, CN;

Guolong Wu, Shanghai, CN;

Zhisen Zhang, Shanghai, CN;

Mingwei Zhou, Shanghai, CN;

Wei Zhu, Shanghai, CN;

Assignee:

Hoffmann-La Roche Inc., Little Falls, NJ (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/506 (2006.01); C07D 498/18 (2006.01); C07D 498/08 (2006.01); C07D 491/18 (2006.01); C07D 453/06 (2006.01); C07D 471/08 (2006.01); C07D 513/08 (2006.01); C07D 417/14 (2006.01); C07D 487/08 (2006.01); C07D 491/08 (2006.01); C07D 498/20 (2006.01);
U.S. Cl.
CPC ...
C07D 498/18 (2013.01); C07D 417/14 (2013.01); C07D 453/06 (2013.01); C07D 471/08 (2013.01); C07D 487/08 (2013.01); C07D 491/08 (2013.01); C07D 491/18 (2013.01); C07D 498/08 (2013.01); C07D 498/20 (2013.01); C07D 513/08 (2013.01); A61K 31/506 (2013.01);
Abstract

The invention provides novel compounds having the general formula: wherein R, R, Rand Rare as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.


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