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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9758492 B1

PDFFull Text
Date of Patent:
Sep. 12, 2017

Filed:

Aug. 26, 2014

Ido inhibitors

Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Jay A. Markwalder, Lahaska, PA (US);

Steven P. Seitz, Swarthmore, PA (US);

James Aaron Balog, Lambertville, NJ (US);

Audris Huang, New Hope, PA (US);

Sunil Kumar Mandal, Bangalore, IN;

Shefali Srivastava, Jaipur, IN;

David K. Williams, Delran, NJ (US);

Libing Chen, Newtown, PA (US);

Assignees:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Syngene International Limited, Bommasandra, Bangalore, IN;

Syngene International Limited, Princeton, NJ (US);

Attorneys:

Serena Farquharson-Torres

Maureen S. Gibbons

Primary Examiner:

Yong Chong

Int. Cl.
CPC ...
C07D 257/04 (2006.01); A61K 31/17 (2006.01); A61K 31/18 (2006.01); A61K 31/381 (2006.01); A61K 31/41 (2006.01); A61K 31/422 (2006.01); A61K 31/427 (2006.01); A61K 31/4439 (2006.01); A61K 31/451 (2006.01); A61K 31/4709 (2006.01); A61K 31/497 (2006.01); A61K 31/50 (2006.01); A61K 31/506 (2006.01); A61K 31/5375 (2006.01); A61K 45/06 (2006.01); C07D 211/14 (2006.01); C07D 237/20 (2006.01); C07D 333/38 (2006.01); C07D 401/10 (2006.01); C07D 407/12 (2006.01); C07D 417/12 (2006.01); C07D 403/12 (2006.01); C07D 309/14 (2006.01); C07D 215/06 (2006.01); C07D 231/12 (2006.01); C07D 333/10 (2006.01); C07D 401/12 (2006.01); C07D 409/12 (2006.01); C07D 411/12 (2006.01); C07D 413/12 (2006.01); C07D 277/22 (2006.01); C07C 275/42 (2006.01); C07C 311/05 (2006.01); C07C 311/09 (2006.01); C07C 317/44 (2006.01); C07B 59/00 (2006.01);
U.S. Cl.
CPC ...
C07D 257/04 (2013.01); A61K 31/17 (2013.01); A61K 31/18 (2013.01); A61K 31/381 (2013.01); A61K 31/41 (2013.01); A61K 31/422 (2013.01); A61K 31/427 (2013.01); A61K 31/4439 (2013.01); A61K 31/451 (2013.01); A61K 31/4709 (2013.01); A61K 31/497 (2013.01); A61K 31/50 (2013.01); A61K 31/506 (2013.01); A61K 31/5375 (2013.01); A61K 45/06 (2013.01); C07B 59/002 (2013.01); C07C 275/42 (2013.01); C07C 311/05 (2013.01); C07C 311/09 (2013.01); C07C 317/44 (2013.01); C07D 211/14 (2013.01); C07D 215/06 (2013.01); C07D 231/12 (2013.01); C07D 237/20 (2013.01); C07D 277/22 (2013.01); C07D 309/14 (2013.01); C07D 333/10 (2013.01); C07D 333/38 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 407/12 (2013.01); C07D 409/12 (2013.01); C07D 411/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07C 2101/02 (2013.01); C07C 2101/04 (2013.01); C07C 2101/08 (2013.01); C07C 2101/14 (2013.01); C07C 2101/16 (2013.01); C07C 2101/18 (2013.01);
Abstract

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or autoimmune diseases utilizing the compounds of the invention.

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