The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 12, 2017

Filed:

Nov. 22, 2012
Applicant:

Sanofi, Paris, FR;

Inventors:

Zsolt Parkanyi, Budapest, HU;

Edit Alattyani, Budapest, HU;

Zoltan Bugir, Érd, HU;

Marton Harsanyi, Dunakeszi, HU;

Assignee:

SANOFI, Paris, FR;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 233/94 (2006.01);
U.S. Cl.
CPC ...
C07D 233/94 (2013.01);
Abstract

Fexinidazole is prepared according to a method which comprises the following steps: a) reacting 1-methyl-2-hydroxymethyl-5-nitro-imidazole with methanesulfonyl chloride in the presence of a suspension of powdered alkaline carbonate in an anhydrous organic solvent suitable for performing nucleophile substitution reactions; b) adding to the resulting reaction medium a solution of 4-methyl-mercapto-phenol in the same organic solvent as referred to in step a); c) separating fexinidazole from the reaction mixture as its hydrochloride salt and d) converting said hydrochloride salt into fexinidazole and optionally, purifying the latter.


Find Patent Forward Citations

Parkanyi, Zsolt. (2017). Method for preparing phenyloxymethyl-nitro-imidazole derivatives and use of same (U.S. Patent No. 9758488). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9758488

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