The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2017
Filed:
Oct. 05, 2015
Applicant:
Cortexyme, Inc., South San Francisco, CA (US);
Inventors:
Andrei Konradi, Burlingame, CA (US);
Stephen S. Dominy, Novato, CA (US);
Casey Crawford Lynch, San Francisco, CA (US);
Craig Coburn, San Rafael, CA (US);
Joseph Vacca, Philadelphia, PA (US);
Assignee:
CORTEXYME, INC., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 247/16 (2006.01); C07C 233/62 (2006.01); C07C 233/78 (2006.01); C07D 417/12 (2006.01); C07D 277/64 (2006.01); C07D 409/12 (2006.01); C07D 213/50 (2006.01);
U.S. Cl.
CPC ...
C07C 233/78 (2013.01); C07C 233/62 (2013.01); C07C 247/16 (2013.01); C07D 213/50 (2013.01); C07D 277/64 (2013.01); C07D 409/12 (2013.01); C07D 417/12 (2013.01);
Abstract
The present invention relates generally to therapeutics targeting the bacterium, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated withinfection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.