The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 12, 2017
Filed:
Aug. 26, 2016
Xiamen University, Xiamen, CN;
Xiamen Innovax Biotech Co., Ltd., Haicang, Xiamen, CN;
Shaowei Li, Xiamen, CN;
Cuiling Song, Xiamen, CN;
Chunyan Yang, Xiamen, CN;
Ying Gu, Xiamen, CN;
Wenxin Luo, Xiamen, CN;
Ningshao Xia, Xiamen, CN;
XIAMEN UNIVERSITY, Xiamen, CN;
XIAMEN INNOVAX BIOTECH CO., LTD., Xiamen, CN;
Abstract
Provided in the present invention are a diphtheria toxin non-toxic mutant CRM197 or a fragment thereof as an adjuvant in a fusion protein and the use thereof to enhance the immunogenicity of a target protein fused therewith, for example, an HEV capsid protein, or an influenza virus M2 protein or an immunogenic fragment thereof. Also provided is a method for enhancing the immunogenicity of a target protein, comprising the fusion expression of the CRM197 or the fragment thereof with the target protein to form a fusion protein. Further provided is a fusion protein comprising the CRM197 or the fragment thereof and a target protein, the CRM197 or the fragment thereof enhancing the immunogenicity of the target protein. The present invention also provides an isolated nucleic acid encoding the fusion protein, a construct and a vector comprising said nucleic acid, and a host cell comprising the nucleic acid.