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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9757397 B1

PDFFull Text
Date of Patent:
Sep. 12, 2017

Filed:

Dec. 19, 2013

Methods of manufacturing topical compositions and apparatus for the same

Applicant:

Novan, Inc., Durham, NC (US);

Inventors:

Eleftherios Kougoulos, Morrisville, NC (US);

Nathan Stasko, Durham, NC (US);

Assignee:

Novan, Inc., Morrisville, NC (US);

Attorney:

Myers Bigel, P.A.

Primary Examiner:

Jared D Barsky

Int. Cl.
CPC ...
A01N 55/00 (2006.01); A61K 31/695 (2006.01); A61K 31/655 (2006.01); A61K 9/00 (2006.01); A61K 47/10 (2017.01); A61K 47/20 (2006.01); A61K 47/38 (2006.01); B01F 7/16 (2006.01); B01F 15/00 (2006.01); A61K 47/34 (2017.01); B01F 7/00 (2006.01); B01F 15/02 (2006.01); B01F 15/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/655 (2013.01); A61K 9/0014 (2013.01); A61K 47/10 (2013.01); A61K 47/20 (2013.01); A61K 47/34 (2013.01); A61K 47/38 (2013.01); B01F 7/00008 (2013.01); B01F 7/164 (2013.01); B01F 15/00012 (2013.01); B01F 15/00071 (2013.01); B01F 15/02 (2013.01); B01F 15/06 (2013.01);
Abstract

Provided according to some embodiments of the invention are methods of manufacturing a pharmaceutical composition. In some embodiments, such methods include homogenizing at a first excipient composition that includes a viscosity agent and at least one solvent to form a first premix composition; separately homogenizing at least one active pharmaceutical ingredient (API) and a second excipient composition to form a second premix composition; and combining the first premix composition and the second premix composition to form the composition. The pre-mixing of constituents may increase the stability of the API and provide uniformity of the dispersion of the constituents throughout the final topical composition.

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