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For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9757368 B1

PDFFull Text
Date of Patent:
Sep. 12, 2017

Filed:

Apr. 21, 2010

Anti-inflammatory agents

Applicants:

Henrik C. Hansen, Calgary, CA;

Gregory S. Wagner, Foster City, CA (US);

Sarah C. Attwell, Calgary, CA;

Kevin G. Mclure, Calgary, CA;

Ewelina B. Kulikowski, Calgary, CA;

Inventors:

Henrik C. Hansen, Calgary, CA;

Gregory S. Wagner, Foster City, CA (US);

Sarah C. Attwell, Calgary, CA;

Kevin G. McLure, Calgary, CA;

Ewelina B. Kulikowski, Calgary, CA;

Assignee:

Resverlogix Corp., Calgary, Alberta, CA;

Attorney:

Finnegan, Henderson, Farabow, Garrett & Dunner, LLP

Primary Examiner:

Sarah Pihonak

Assistant Examiner:

Jason A Deck

Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/517 (2006.01); C07D 401/12 (2006.01); C07D 403/10 (2006.01); C07D 413/10 (2006.01); C07D 471/04 (2006.01); A61K 31/519 (2006.01); C07D 405/10 (2006.01); C07D 403/12 (2006.01); C07D 413/12 (2006.01); C07D 217/24 (2006.01); A61K 31/472 (2006.01); A61P 9/00 (2006.01); A61P 29/00 (2006.01); C07D 239/91 (2006.01); A61K 31/47 (2006.01); C07D 403/04 (2006.01); C07D 405/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/47 (2013.01); C07D 239/91 (2013.01); C07D 401/12 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 405/04 (2013.01); C07D 413/12 (2013.01);
Abstract

Disclosed are methods of regulating interleukin-6 (IL-6) and/or vascular cell adhesion molecule-1 (VCAM-1) and methods of treating and/or preventing cardiovascular and inflammatory diseases and related disease states, such as, for example, atherosclerosis, asthma, arthritis, cancer, multiple sclerosis, psoriasis, and inflammatory bowel diseases, and autoimmune disease(s) by administering a naturally occurring or synthetic quinazolone derivative. The invention provides novel synthetic quinazolone compounds, as well as pharmaceutical compositions comprising those compounds.

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