The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2017
Filed:
Jun. 10, 2016
Applicant:
Life Technologies Corporation, Carlsbad, CA (US);
Inventors:
Anilkumar R. Kore, Austin, TX (US);
Shanmugasundaram Muthian, Austin, TX (US);
Kyle Gee, Springfield, OR (US);
Assignee:
Life Technologies Corporation, Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/00 (2006.01); C12N 15/67 (2006.01); A61K 31/7088 (2006.01); A61K 31/7084 (2006.01); A61K 31/7115 (2006.01); A61K 31/712 (2006.01); C07C 247/04 (2006.01); C07D 213/82 (2006.01); C07H 19/207 (2006.01); C07H 21/02 (2006.01); C12Q 1/68 (2006.01); C12N 15/11 (2006.01); A61K 39/12 (2006.01); A61K 39/39 (2006.01); C07C 323/60 (2006.01); C12N 7/00 (2006.01); C12P 19/34 (2006.01); C07H 1/00 (2006.01); C07H 1/02 (2006.01); C07H 1/04 (2006.01); A61K 48/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/67 (2013.01); A61K 31/7084 (2013.01); A61K 31/7088 (2013.01); A61K 31/712 (2013.01); A61K 31/7115 (2013.01); A61K 39/12 (2013.01); A61K 39/39 (2013.01); C07C 247/04 (2013.01); C07C 323/60 (2013.01); C07D 213/82 (2013.01); C07H 19/207 (2013.01); C07H 21/02 (2013.01); C12N 7/00 (2013.01); C12N 15/11 (2013.01); C12P 19/34 (2013.01); C12Q 1/68 (2013.01); A61K 48/00 (2013.01); A61K 2039/53 (2013.01); A61K 2039/55511 (2013.01); C07H 1/00 (2013.01); C07H 1/02 (2013.01); C07H 1/04 (2013.01); C12N 2770/36134 (2013.01); C12N 2770/36171 (2013.01);
Abstract
Alkynyl-derivatized cap analogs, alkynyl-modified capped RNA, 1,4-disubstituted triazole-derivatized capped RNA, methods of preparation, methods of isolation, and uses thereof are provided. The 'click' modification facilitates detection and isolation of capped RNAs and the 1,4-disubstituted triazole derivatives formed by the 'click' reaction are useful for producing RNA transcripts and encoded protein.