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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9752151 B1

PDFFull Text
Date of Patent:
Sep. 05, 2017

Filed:

Mar. 27, 2014

Composition for treatment or metastasis suppression of cancers which includes p34 expression inhibitor or activity inhibitor as active ingredient

Applicants:

The Asan Foundation, Seoul, KR;

University of Ulsan Foundation for Industry Cooperation, Ulsan, KR;

Inventors:

Tae Won Kim, Seoul, KR;

Dong Hoon Jin, Seoul, KR;

Seung Woo Hong, Seoul, KR;

Jai Hee Moon, Seoul, KR;

Jae Sik Shin, Seoul, KR;

Jin Sun Kim, Seoul, KR;

Kyung Ah Jung, Seoul, KR;

Jung Shin Lee, Seoul, KR;

Eun Kyung Choi, Seoul, KR;

Jae Lyun Lee, Seoul, KR;

Yong Sang Hong, Seoul, KR;

Kyu Pyo Kim, Seoul, KR;

Ky Youb Nam, Seoul, KR;

Bong Cheol Kim, Seoul, KR;

Assignees:

The Asan Foundation, Seoul, KR;

University of Ulsan Foundation for Industry Cooperation, Ulsan, KR;

Attorney:

McDonnell Boehnen Hulbert & Berghoff LLP

Primary Examiner:

Marcos Sznaidman

Int. Cl.
CPC ...
A01N 43/52 (2006.01); A61K 31/415 (2006.01); C12N 15/113 (2010.01); A61K 31/4245 (2006.01); C12Q 1/68 (2006.01); G01N 33/50 (2006.01); A23L 33/13 (2016.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A23L 33/13 (2016.08); A61K 31/4245 (2013.01); C12N 15/113 (2013.01); C12Q 1/6886 (2013.01); G01N 33/5011 (2013.01); A23V 2002/00 (2013.01); C12N 2310/11 (2013.01); C12N 2310/12 (2013.01); C12N 2310/122 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01);
Abstract

The present invention relates to a composition for treatment or metastasis suppression of cancers which includes a p34 expression inhibitor or activity inhibitor as an active ingredient. According to the present invention, the p34 protein knock-down causes monoubiquitination of PTEN and accordingly nuclear localization of PTEN is induced, as a result, an Akt pathway which is related to survival, proliferation, invasive properties and metastatic properties of tumors is inhibited, and thus there is an effect of significantly reducing clonogenic potential and tumor forming potential of various cancer cells which simultaneously express PTEN and NEDD4-1. Consequently, the p34 gene expression inhibitor or p34 protein activity inhibitor according to the present invention can be effectively used as a treatment agent or a metastasis suppression agent for cancers.

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