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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9752121 B1

PDFFull Text
Date of Patent:
Sep. 05, 2017

Filed:

Aug. 14, 2012

In vitro modelling of haematopoietic stem cell medullary nests: a tool for studying the regulation of haematopoiesis, evaluating the nesting potential of a haematopoietic graft and testing the pharmacotoxicology of medicaments

Applicants:

Jean-jacques Lataillade, Elancourt, FR;

Marie-caroline Le Bousse-kerdiles, Bourg-la-Reine, FR;

Inventors:

Jean-Jacques Lataillade, Elancourt, FR;

Marie-Caroline Le Bousse-Kerdiles, Bourg-la-Reine, FR;

Assignees:

ETAT FRANCAIS (MINISTERE DE LA DEFENSE), SERVICE DE SANTE DES ARMEES, Paris, FR;

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), Paris, FR;

Attorney:

Knobbe Martens Olson & Bear, LLP

Primary Examiner:

Allison Fox

Int. Cl.
CPC ...
C12N 5/077 (2010.01); C12N 5/0775 (2010.01); C12N 5/0789 (2010.01); C12N 5/071 (2010.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0647 (2013.01); C12N 5/0697 (2013.01); G01N 33/5023 (2013.01); G01N 33/5047 (2013.01); C12N 2500/02 (2013.01); C12N 2501/125 (2013.01); C12N 2501/145 (2013.01); C12N 2501/26 (2013.01); C12N 2502/1142 (2013.01); C12N 2502/1171 (2013.01); C12N 2502/1305 (2013.01); C12N 2502/1311 (2013.01); C12N 2502/1352 (2013.01); C12N 2502/1358 (2013.01); C12N 2502/28 (2013.01); C12N 2533/18 (2013.01); C12N 2533/70 (2013.01); C12N 2533/90 (2013.01); G01N 2500/10 (2013.01);
Abstract

The present invention relates to a culture support for cultivating hematopoietic stem cells (HSCs) and/or hematopoietic progenitors (HPs), comprising a calcium biomaterial, osteoclasts, endothelial cells and mesenchymatous stem cells (MSCs) and/or osteoblasts and/or adipocytes. The present invention also relates to a method for preparing such a culture support, and an in vitro HSC and/or HP cultivation method. The use of such a culture support for studying cellular mechanisms involved in hematopoiesis and/or differentiation of HSC/HPs and/or for studying the efficacy and/or the toxicity of a medicament candidate is also described.

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