The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2017
Filed:
Dec. 04, 2015
Modernatx, Inc., Cambridge, MA (US);
Stephen G. Hoge, Brookline, MA (US);
William Joseph Issa, Dedham, MA (US);
Edward John Miracco, Cambridge, MA (US);
Jennifer Nelson, Brookline, MA (US);
John Reynders, Newton, MA (US);
Matthew Stanton, Marlton, NJ (US);
ModernaTX, Inc., Cambridge, MA (US);
Abstract
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.