The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2017
Filed:
Sep. 07, 2012
Tracy J. Matray, Snohomish, WA (US);
Iwona M. Maciagiewicz, Oak Park, IL (US);
Michael E. Houston, Jr., Sammamish, WA (US);
Tracy J. Matray, Snohomish, WA (US);
Iwona M. Maciagiewicz, Oak Park, IL (US);
Michael E. Houston, Jr., Sammamish, WA (US);
Marina Biotech, Inc., City of industry, CA (US);
Abstract
Processes for synthesis of conformationally restricted nucleomonomers (CRN) by ozonolysis or oxidation of a 2'-vinyl substituted nucleoside precursor with protected 3′-hydroxyl, 4′-hydroxymethyl and 5′-hydroxyl positions. The CRN nucleomonomers can be used to prepare nucleic acid compounds. CRN nucleomonomers for nucleic acid compounds can be prepared in high yields and in multi-gram scale. The nucleic acid compounds can be of various regulatory classes such as antisense RNA for therapeutic modalities useful for treating or preventing diseases or disorders by up- or down-regulating the expression of genes and other nucleic acid based regulatory systems in a cell.