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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9751881 B1

PDFFull Text
Date of Patent:
Sep. 05, 2017

Filed:

Jul. 28, 2014

Inhibitors of the renal outer medullary potassium channel

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Haifeng Tang, Metuchen, NJ (US);

Barbara Pio, West Orange, NJ (US);

Jinlong Jiang, Scotch Plains, NJ (US);

Alexander Pasternak, Princeton, NJ (US);

Shuzhi Dong, Plainsboro, NJ (US);

Ronald Dale Ferguson, II, Scotch Plains, NJ (US);

Zack Zhiqiang Guo, Morganville, NJ (US);

Harry Chobanian, Aberdeen, NJ (US);

Jessica Frie, Harleysville, PA (US);

Yan Guo, Westfield, NJ (US);

Zhicai Wu, Montvale, NJ (US);

Yang Yu, Edison, NJ (US);

Ming Wang, Belle Mead, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Baerbel R. Brown

Catherine D. Fitch

Primary Examiner:

Noble Jarrell

Assistant Examiner:

John S Kenyon

Int. Cl.
CPC ...
C07D 471/10 (2006.01); C07D 451/00 (2006.01); C07D 493/04 (2006.01); C07D 498/10 (2006.01); A61K 31/435 (2006.01); A61K 31/444 (2006.01); A61K 31/46 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01); A61K 31/506 (2006.01); A61K 31/5386 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 471/10 (2013.01); A61K 31/435 (2013.01); A61K 31/444 (2013.01); A61K 31/46 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/5386 (2013.01); A61K 45/06 (2013.01); C07D 451/00 (2013.01); C07D 493/04 (2013.01); C07D 498/10 (2013.01);
Abstract

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

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