The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 05, 2017

Filed:

Jul. 11, 2014
Applicant:

Beijing Fswelcome Technology Development Co., Ltd., Beijing, CN;

Inventors:

Chunjing Wang, Beijing, CN;

Junyi Wang, Beijing, CN;

Zejun Gao, Beijing, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/46 (2006.01); C07D 453/02 (2006.01); A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61K 31/137 (2006.01); A61K 31/439 (2006.01);
U.S. Cl.
CPC ...
C07D 453/02 (2013.01); A61K 9/007 (2013.01); A61K 9/008 (2013.01); A61K 9/0043 (2013.01); A61K 9/20 (2013.01); A61K 9/4808 (2013.01); A61K 31/137 (2013.01); A61K 31/439 (2013.01);
Abstract

The present invention discloses a class of quinine compounds and pharmaceutically acceptable salts, solvates, prodrugs or optical isomers thereof. Also disclosed in the present invention are that the above compounds have a selective antagonistic effect on the receptor subtypes of Mand M, but have no significant effect on Mreceptor subtype, and the above compounds are characterized by rapid action, long-lasting efficacy, and low toxic and side-effects when used to treat rhinitis, post-cold rhinitis, chronic trachitis, airway hyperresponsiveness, asthma, chronic obstructive pulmonary diseases, cough, urinary incontinence, frequent urination, unstable bladder syndrome, bladder spasms, bladder inflammation and gastrointestinal diseases such as irritable bowel syndrome, spastic colitis, as well as duodenal and gastric ulcers.


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