The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2017
Filed:
May. 02, 2016
Applicant:
Advenchen Pharmaceuticals, Llc, Moorpark, CA (US);
Inventors:
Guoqing Paul Chen, Westlake Village, CA (US);
Changren Yan, Camarillo, CA (US);
Assignee:
Advenchen Pharmaceuticals, LLC, Moorpark, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07C 57/145 (2006.01); C07C 55/10 (2006.01); A61K 31/4709 (2006.01); A61K 45/06 (2006.01); A61K 33/24 (2006.01); A61K 31/337 (2006.01); A61K 39/395 (2006.01); C07K 16/22 (2006.01); A61K 31/555 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61K 31/337 (2013.01); A61K 31/4709 (2013.01); A61K 31/555 (2013.01); A61K 33/24 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); C07C 55/10 (2013.01); C07C 57/145 (2013.01); C07K 16/22 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01);
Abstract
The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine (AL3818). A stable crystalline form of Al3818 has been prepared. Salts and their crystalline forms of AL3818 have been also prepared. Anti-cancer and optometric activities of AL3818 and its salts have been further tested. New process has been outlined in Scheme I.