IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9751858 B1

PDFFull Text
Date of Patent:
Sep. 05, 2017

Filed:

Apr. 27, 2016

3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals

Applicant:

Sanofi, Paris, FR;

Inventors:

Sven Ruf, Frankfurt am Main, DE;

Josef Pernerstorfer, Frankfurt am Main, DE;

Thorsten Sadowski, Frankfurt am Main, DE;

Georg Horstick, Frankfurt am Main, DE;

Herman Schreuder, Frankfurt am Main, DE;

Christian Buning, Frankfurt am Main, DE;

Klaus Wirth, Frankfurt am Main, DE;

Assignee:

SANOFI, Paris, FR;

Attorney:

Morrison & Foerster LLP

Primary Examiner:

Matthew Coughlin

Assistant Examiner:

Po-Chih Chen

Int. Cl.
CPC ...
C07D 401/06 (2006.01); C07D 277/56 (2006.01); A61K 31/426 (2006.01); C07D 233/90 (2006.01); A61K 31/4164 (2006.01); C07D 261/18 (2006.01); A61K 31/42 (2006.01); C07D 263/34 (2006.01); A61K 31/421 (2006.01); C07D 231/14 (2006.01); A61K 31/415 (2006.01); C07D 271/06 (2006.01); A61K 31/4245 (2006.01); C07D 249/10 (2006.01); A61K 31/4196 (2006.01); C07D 307/68 (2006.01); A61K 31/341 (2006.01); A61K 31/454 (2006.01); A61K 45/06 (2006.01); C07D 271/10 (2006.01); C07D 277/32 (2006.01); C07D 285/08 (2006.01);
U.S. Cl.
CPC ...
C07D 401/06 (2013.01); A61K 31/341 (2013.01); A61K 31/415 (2013.01); A61K 31/4164 (2013.01); A61K 31/4196 (2013.01); A61K 31/42 (2013.01); A61K 31/421 (2013.01); A61K 31/426 (2013.01); A61K 31/4245 (2013.01); A61K 31/454 (2013.01); A61K 45/06 (2013.01); C07D 231/14 (2013.01); C07D 233/90 (2013.01); C07D 249/10 (2013.01); C07D 261/18 (2013.01); C07D 263/34 (2013.01); C07D 271/06 (2013.01); C07D 271/10 (2013.01); C07D 277/32 (2013.01); C07D 277/56 (2013.01); C07D 285/08 (2013.01); C07D 307/68 (2013.01);
Abstract

The present invention relates to compounds of the formula I, wherein Ht, G, R, R, R, Rand Rhave the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

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