The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2017
Filed:
Jun. 04, 2014
Applicant:
Virginia Commonwealth University, Richmond, VA (US);
Inventors:
Paul B. Fisher, Richmond, VA (US);
Swadesh K. Das, Richmond, VA (US);
Rupesh Dash, Richmond, VA (US);
Devanand Sarkar, Richmond, VA (US);
Siddik Sarkar, Richmond, VA (US);
Jolene Windle, Richmond, VA (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 47/00 (2006.01); A61K 49/00 (2006.01); C12N 15/00 (2006.01); C12N 5/00 (2006.01); A01K 67/027 (2006.01); A61K 35/761 (2015.01); C12N 15/86 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0058 (2013.01); A01K 67/0275 (2013.01); A61K 35/761 (2013.01); A61K 49/005 (2013.01); A61K 49/0008 (2013.01); C12N 15/86 (2013.01); A01K 2207/12 (2013.01); A01K 2217/052 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0331 (2013.01); A01K 2267/0393 (2013.01); C12N 2015/8536 (2013.01); C12N 2015/8572 (2013.01); C12N 2710/10332 (2013.01); C12N 2830/008 (2013.01); C12N 2830/34 (2013.01);
Abstract
Recombinant vectors in which expression of one or more elements (e.g. genes required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by a truncated CCN 1 cancer selective promoter (tCCN1-Prom) are provided, as are cells and transgenic animals that contain such vectors. The vectors are used in cancer therapy and/or diagnostics, and the transgenic mice are used to monitor cancer progression, e.g. in screening assays.