The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 2017
Filed:
Oct. 16, 2015
Applicant:
Tufts University, Boston, MA (US);
Inventors:
Philip G. Haydon, Boston, MA (US);
Jinbo Lee, Andover, MA (US);
Assignee:
TUFTS UNIVERSITY, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/04 (2006.01); A61K 31/70 (2006.01); A61K 31/7072 (2006.01); A61K 31/7052 (2006.01); A61K 31/706 (2006.01); A61K 31/7068 (2006.01); A61K 31/7064 (2006.01); A61K 31/7042 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 405/04 (2006.01); C07H 19/067 (2006.01); C07F 9/09 (2006.01); C07F 9/22 (2006.01); C07F 9/6558 (2006.01); C07F 9/6574 (2006.01); C07H 19/06 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7072 (2013.01); A61K 9/0019 (2013.01); A61K 31/706 (2013.01); A61K 31/7042 (2013.01); A61K 31/7052 (2013.01); A61K 31/7064 (2013.01); A61K 31/7068 (2013.01); C07D 405/04 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07F 9/09 (2013.01); C07F 9/22 (2013.01); C07F 9/65586 (2013.01); C07F 9/65742 (2013.01); C07F 9/65744 (2013.01); C07H 19/06 (2013.01); C07H 19/067 (2013.01);
Abstract
This disclosure relates to prodrugs of uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those prodrugs of the UDP derivatives and methods of using those prodrugs or compositions in treating disorders that are responsive to ligands, such as agonists, of PYreceptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma, and inflammatory conditions.