The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 05, 2017

Filed:

Oct. 08, 2015
Applicant:

Chemocentryx, Inc., Mountain View, CA (US);

Inventors:

Xi Chen, East Palo Alto, CA (US);

Dean R. Dragoli, Los Altos, CA (US);

Pingchen Fan, Fremont, CA (US);

Juan C. Jaen, Burlingame, CA (US);

Yandong Li, San Jose, CA (US);

Jay P. Powers, Pacifica, CA (US);

Viengkham Malathong, Belmont, CA (US);

Sreenivas Punna, Sunnyvale, CA (US);

Hiroko Tanaka, Foster City, CA (US);

Penglie Zhang, Foster City, CA (US);

Assignee:

CHEMOCENTRYX, INC., Mountain View, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 233/88 (2006.01); A61K 31/437 (2006.01); A61K 31/4178 (2006.01); A61K 45/06 (2006.01); C07D 401/12 (2006.01); A61K 31/4155 (2006.01); C07D 231/40 (2006.01); A61K 31/4192 (2006.01); A61K 31/4196 (2006.01); C07D 471/04 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4155 (2013.01); A61K 31/4178 (2013.01); A61K 31/4192 (2013.01); A61K 31/4196 (2013.01); A61K 31/437 (2013.01); A61K 45/06 (2013.01); C07D 231/40 (2013.01); C07D 233/88 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 471/04 (2013.01);
Abstract

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.


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