The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2017
Filed:
Jan. 13, 2011
Applicants:
Laurie H. Glimcher, New York, NY (US);
Dallas C. Jones, Brookline, MA (US);
Marc Wein, Brookline, MA (US);
Inventors:
Laurie H. Glimcher, New York, NY (US);
Dallas C. Jones, Brookline, MA (US);
Marc Wein, Brookline, MA (US);
Assignee:
Cornell University, Ithaca, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61K 31/713 (2006.01); A61K 35/28 (2015.01); C07K 16/18 (2006.01); C12N 15/63 (2006.01); G01N 33/68 (2006.01); A61K 31/7088 (2006.01); A61K 38/17 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12N 15/63 (2013.01); A61K 31/7088 (2013.01); A61K 31/713 (2013.01); A61K 38/1709 (2013.01); G01N 33/5044 (2013.01); G01N 33/6893 (2013.01); G01N 2500/00 (2013.01); G01N 2800/105 (2013.01); G01N 2800/108 (2013.01);
Abstract
This invention is based, at least in part, on the discovery that Shn2 and Shn3 play an important role in skeletal remodeling and skeletal patterning. Accordingly, the present invention provides methods for identifying medulators of Shn2 activity and methods for modulating bone formation and mineralization and Shn2-associated disorders using agents that modulate Shn2 expression and/or activity, in addition to methods for modulating Shn2 and Shn3.