The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2017
Filed:
Jan. 18, 2007
Applicants:
Monica Florio, Woodland Hills, CA (US);
Aleksandar Francki, Santa Monica, CA (US);
Wen-ghih Tsang, Sherman Oaks, CA (US);
Inventors:
Monica Florio, Woodland Hills, CA (US);
Aleksandar Francki, Santa Monica, CA (US);
Wen-Ghih Tsang, Sherman Oaks, CA (US);
Assignee:
ReNeuron, Inc., Guildford, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/00 (2006.01); C12N 5/071 (2010.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0676 (2013.01); C12N 5/0677 (2013.01); A61K 2035/126 (2013.01); C12N 2501/105 (2013.01); C12N 2501/135 (2013.01); C12N 2501/48 (2013.01); C12N 2501/70 (2013.01); C12N 2509/00 (2013.01); C12N 2533/32 (2013.01); C12N 2533/74 (2013.01);
Abstract
The invention relates to the discovery that the proliferation and survival of pancreatic progenitor cells can be enhanced by contacting the cells with, (1) a caspase inhibitor sufficient to reduce apoptosis in the pancreatic endocrine cells; and, (2) a growth factor in an amount sufficient to increase the level of activated Akt in the pancreatic endocrine cells.