The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 29, 2017

Filed:

Mar. 13, 2017
Applicant:

Ablynx N.v., Zwijnaarde, BE;

Inventors:

Marie-Ange Buyse, Merelbeke, BE;

Joachim Boucneau, De Pinte, BE;

Peter Casteels, Erpe-Mere, BE;

Gino Van Heeke, Eine, BE;

Assignee:

Ablynx N.V., Ghent-Zwijnaarde, BE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/24 (2006.01);
U.S. Cl.
CPC ...
C07K 16/241 (2013.01); C07K 2317/24 (2013.01); C07K 2317/569 (2013.01); C07K 2317/94 (2013.01);
Abstract

The present invention relates to amino acid sequences, compounds and polypeptides binding to tumor necrosis factor alpha ('TNF' or 'TNF-alpha'). In particular, the present invention relates to improved heavy-chain immunoglobulin single variable domains (also referred to herein as “ISV's” or “ISVDs”) binding to tumor necrosis factor alpha, as well as to proteins, polypeptides and other constructs, compounds, molecules or chemical entities that comprise such ISVDs, collectively TNF binders. Other aspects, embodiments, features, uses and advantages of the invention will be clear to the skilled person based on the disclosure herein.


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