The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 29, 2017

Filed:

May. 17, 2013
Applicant:

Adda Biotech Inc., Beijing, CN;

Inventor:

Shulin Qin, Beijing, CN;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 36/26 (2006.01); C07K 14/545 (2006.01); C07K 14/605 (2006.01); C07K 14/575 (2006.01); C07K 14/62 (2006.01); C07K 14/645 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/545 (2013.01); C07K 14/575 (2013.01); C07K 14/605 (2013.01); C07K 14/62 (2013.01); C07K 14/645 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/31 (2013.01); C07K 2319/74 (2013.01);
Abstract

The present invention relates to the field of biopharmaceutics, and in particular to a protein, a protein conjugate, a pharmaceutical composition and its use for treating diabetes. The fusion protein of the present invention is obtained by linking two polypeptides, wherein one polypeptide is an interleukin-1 receptor antagonistic protein or an analog thereof, and another polypeptide is GLP-1 receptor binding polypeptide or an analog thereof, or an insulin receptor binding polypeptide or an analog thereof, or a GIP receptor binding polypeptide or an analog thereof. The fusion proteins of the present invention and conjugates thereof have a significant efficacy in treating diabetes, and can be used in a lower dose, resulting in a marked reduction in side effects.


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