The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 29, 2017

Filed:

Jul. 18, 2012
Applicants:

Steven Bergens, Alberta, CA;

Jeremy M. John, Alberta, CA;

Inventors:

Steven Bergens, Alberta, CA;

Jeremy M. John, Alberta, CA;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F 15/00 (2006.01); C07C 209/50 (2006.01); C07C 213/00 (2006.01); C07D 295/027 (2006.01); C07B 31/00 (2006.01); B01J 31/18 (2006.01); B01J 31/24 (2006.01); C07C 303/40 (2006.01); C07C 231/08 (2006.01); C07D 201/02 (2006.01); C07D 295/023 (2006.01); C07C 29/149 (2006.01); C07C 41/26 (2006.01);
U.S. Cl.
CPC ...
C07F 15/0053 (2013.01); B01J 31/1805 (2013.01); B01J 31/189 (2013.01); B01J 31/2409 (2013.01); B01J 31/2452 (2013.01); C07B 31/00 (2013.01); C07C 29/149 (2013.01); C07C 41/26 (2013.01); C07C 209/50 (2013.01); C07C 213/00 (2013.01); C07C 231/08 (2013.01); C07C 303/40 (2013.01); C07D 201/02 (2013.01); C07D 295/023 (2013.01); C07D 295/027 (2013.01); C07F 15/0046 (2013.01); B01J 2231/643 (2013.01); B01J 2531/0244 (2013.01); B01J 2531/0255 (2013.01); B01J 2531/0266 (2013.01); B01J 2531/821 (2013.01); C07B 2200/07 (2013.01);
Abstract

There is provided a process for the reduction of one or more amide moieties in a compound comprising contacting the compound with hydrogen gas and a transition metal catalyst in the presence or absence of a base under conditions for the reduction an amide bond. The presently described processes can be performed at low catalyst loading using relatively mild temperature and pressures, and optionally, in the presence or absence of a base or high catalyst loadings using low temperatures and pressures and high loadings of base to effect dynamic kinetic resolution of achiral amides.


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