The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2017
Filed:
Aug. 16, 2012
Applicant:
Samy O. Meroueh, Carmel, IN (US);
Inventor:
Samy O. Meroueh, Carmel, IN (US);
Assignee:
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/36 (2006.01); C07D 405/04 (2006.01); A61K 31/402 (2006.01); A61K 31/445 (2006.01); A61K 31/453 (2006.01); A61K 31/454 (2006.01); C07D 207/277 (2006.01); C07D 211/94 (2006.01); C07D 317/50 (2006.01); C07D 401/04 (2006.01);
U.S. Cl.
CPC ...
C07D 405/04 (2013.01); A61K 31/36 (2013.01); A61K 31/402 (2013.01); A61K 31/445 (2013.01); A61K 31/453 (2013.01); A61K 31/454 (2013.01); C07D 207/277 (2013.01); C07D 211/94 (2013.01); C07D 317/50 (2013.01); C07D 401/04 (2013.01);
Abstract
Compounds and methods for treating or preventing cancer associated with binding to the urokinase receptor are provided. Biological processes affected by the compounds include cell migration, cell growth, cell adhesion, angiogenesis, cancer cell invasion, apoptosis, tumor formation, tumor progression, metastasis, degradation of the extracellular matrix, pericellular proteolysis, activation of plasminogen, changes in the levels of an extracellular protease, and changes in the levels of a VEGF receptor.