The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 29, 2017

Filed:

Jun. 30, 2016
Applicants:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Elexopharm Gmbh, Saarbrucken, DE;

Inventors:

Amjad Ali, Freehold, NJ (US);

Michael Man-Chu Lo, Edison, NJ (US);

Edward Metzger, Somerset, NJ (US);

Lina Yin, Saarbrucken, DE;

Rolf Hartmann, Saarbrucken, DE;

Qingzhong Hu, Saarbrucken, DE;

Ralf Heim, Saarbrucken, DE;

Christina Zimmer, Volklingen, DE;

Assignees:

Merck Sharp & Dohme Corp, Rahway, NJ (US);

ElexoPharm GmbH, Saarbrucken, DE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/04 (2006.01); A61K 31/4709 (2006.01); A61K 31/4439 (2006.01); A61K 45/06 (2006.01); C07D 409/14 (2006.01); A61K 31/4725 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); A61K 31/4439 (2013.01); A61K 31/4709 (2013.01); A61K 31/4725 (2013.01); A61K 45/06 (2013.01); C07D 409/14 (2013.01);
Abstract

This invention relates to indoline compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variables are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.


Find Patent Forward Citations

Loading…