The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2017
Filed:
Oct. 10, 2012
Applicants:
Universidad Nacional DE Quilmes, Buenos Aires, AR;
Chemo Research, S.l., Madrid, ES;
Inventors:
Pablo Lorenzano Menna, Buenos Aires, AR;
Daniel Fernando Alonso, Buenos Aires, AR;
Daniel Eduardo Gómez, Buenos Aires, AR;
Julieta Comin, Buenos Aires, AR;
Assignees:
UNIVERSIDAD NACIONAL DE QUILMES, Buenos Aires, AR;
CHEMO RESEARCH, S.L., Madrid, ES;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/505 (2006.01); A61K 31/155 (2006.01); C07D 239/42 (2006.01); C07C 277/08 (2006.01); C07C 279/18 (2006.01); C07D 213/75 (2006.01); C07D 333/36 (2006.01); C07D 233/88 (2006.01); C07D 235/30 (2006.01); C07D 263/48 (2006.01); C07D 207/14 (2006.01); C07D 277/48 (2006.01); C07D 307/66 (2006.01);
U.S. Cl.
CPC ...
C07C 279/18 (2013.01); A61K 31/155 (2013.01); A61K 31/505 (2013.01); C07C 277/08 (2013.01); C07D 207/14 (2013.01); C07D 213/75 (2013.01); C07D 233/88 (2013.01); C07D 235/30 (2013.01); C07D 239/42 (2013.01); C07D 263/48 (2013.01); C07D 277/48 (2013.01); C07D 307/66 (2013.01); C07D 333/36 (2013.01);
Abstract
Provided herein are phenyl-guanidine derivatives for the inhibition of Rac1 which blocks its interaction with guanosine exchange factors (GEFs) belonging to the DBL family as agents for the treatment of aggressive and/or resistant tumors, as well as pharmaceutical compositions comprising them, their use in therapy and processes for their preparation.