The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2017
Filed:
Sep. 24, 2015
Applicant:
Alma Mater Studiorum—universita Di Bologna, Bologna, IT;
Inventors:
Gabriella Campadelli, Bologna, IT;
Laura Menotti, Bologna, IT;
Assignee:
ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA, Bologna, IT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/00 (2006.01); A61K 35/76 (2015.01); A61K 49/04 (2006.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01); A61K 39/245 (2006.01); C07K 14/035 (2006.01); A61K 35/763 (2015.01);
U.S. Cl.
CPC ...
A61K 35/763 (2013.01); A61K 49/04 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C07K 2317/622 (2013.01); C07K 2319/33 (2013.01); C07K 2319/61 (2013.01); C07K 2319/74 (2013.01); C12N 2710/16621 (2013.01); C12N 2710/16622 (2013.01); C12N 2710/16632 (2013.01); C12N 2710/16633 (2013.01); C12N 2710/16651 (2013.01); C12N 2710/16722 (2013.01); C12N 2810/85 (2013.01);
Abstract
A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion; the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC; uses of the modified HSV and a process of the preparation thereof are also disclosed.