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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9744171 B1

PDFFull Text
Date of Patent:
Aug. 29, 2017

Filed:

Mar. 06, 2013

Positive allosteric modulators for melanocortin receptors

Applicant:

Vanderbilt University, Nashville, TN (US);

Inventors:

Roger D. Cone, Nashville, TN (US);

Julien A. Sebag, Nashville, TN (US);

Jacques Pantel, Paris, FR;

Savannah Y. Williams, Nashville, TN (US);

David C. Weaver, Franklin, TN (US);

Gary A. Sulikowski, Brentwood, TN (US);

Craig W. Lindsley, Brentwood, TN (US);

Padma S. Portonova, Brentwood, TN (US);

Chao Zhang, Nashville, TN (US);

Assignee:

Vanderbilt University, Nashville, TN (US);

Attorney:

Tarolli, Sundheim, Covell & Tummino LLP

Primary Examiner:

Dennis Heyer

Assistant Examiner:

Daniel M Podgorski

Int. Cl.
CPC ...
A61K 31/4965 (2006.01); A61K 31/519 (2006.01); A61K 31/4192 (2006.01); C07D 231/08 (2006.01); C07D 333/38 (2006.01); C07D 401/12 (2006.01); C07D 403/04 (2006.01); C07D 409/12 (2006.01); C07D 417/12 (2006.01); C07D 249/06 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 491/04 (2006.01); C07D 495/04 (2006.01); C07D 277/18 (2006.01); C07D 277/54 (2006.01); C07D 209/16 (2006.01); C07D 295/12 (2006.01); C07D 307/82 (2006.01); A61K 31/343 (2006.01); A61K 31/381 (2006.01); A61K 31/415 (2006.01); A61K 31/4162 (2006.01); A61K 31/427 (2006.01); A61K 31/437 (2006.01); A61K 31/4704 (2006.01); A61K 31/4709 (2006.01); A61K 31/4741 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61K 31/517 (2006.01); A61K 31/166 (2006.01); A61K 31/216 (2006.01); A61K 31/4045 (2006.01); A61K 31/4152 (2006.01); A61K 31/426 (2006.01); A61K 31/4355 (2006.01); A61K 31/436 (2006.01); A61K 31/47 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 31/166 (2013.01); A61K 31/216 (2013.01); A61K 31/343 (2013.01); A61K 31/381 (2013.01); A61K 31/4045 (2013.01); A61K 31/415 (2013.01); A61K 31/4152 (2013.01); A61K 31/4162 (2013.01); A61K 31/4192 (2013.01); A61K 31/426 (2013.01); A61K 31/427 (2013.01); A61K 31/436 (2013.01); A61K 31/437 (2013.01); A61K 31/4355 (2013.01); A61K 31/47 (2013.01); A61K 31/4704 (2013.01); A61K 31/4709 (2013.01); A61K 31/4741 (2013.01); A61K 31/495 (2013.01); A61K 31/496 (2013.01); A61K 31/506 (2013.01); A61K 31/517 (2013.01); C07D 209/16 (2013.01); C07D 231/08 (2013.01); C07D 249/06 (2013.01); C07D 277/18 (2013.01); C07D 277/54 (2013.01); C07D 295/12 (2013.01); C07D 307/82 (2013.01); C07D 333/38 (2013.01); C07D 401/12 (2013.01); C07D 403/04 (2013.01); C07D 409/12 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 491/04 (2013.01); C07D 495/04 (2013.01); G01N 33/502 (2013.01); G01N 2333/46 (2013.01); G01N 2500/10 (2013.01);
Abstract

Positive allosteric modulators of melanocortin receptors, especially allosteric potentiators of the receptors MC3R and MC4R are described herein. Also provided are pharmaceutical compositions containing the positive allosteric modulators and methods of treating obesity or an obesity-related disorder such as type 2 diabetes, comprising administering an effective amount of the positive allosteric modulator.

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