The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2017
Filed:
Apr. 06, 2015
Applicant:
Crown Bioscience Inc. (Taicang), Taicang, CN;
Inventors:
Qian Shi, Taicang, CN;
Yanmei Sun, Taicang, CN;
Assignee:
CROWN BIOSCIENCE INC. (TAICANG), Taicang, CN;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); A61K 48/00 (2006.01); A61K 49/00 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0271 (2013.01); A61K 49/0008 (2013.01); A01K 2207/12 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0331 (2013.01);
Abstract
The present invention provides an immuno-deficient animal useful as an animal model for a human disease associated with a first mutation of a target gene, wherein the animal comprises (a) a first human xenograft comprising the target gene comprising the first mutation; (b) a second human xenograft comprising the target gene but lacking the first mutation, wherein the first human xenograft and second human xenograft are isogenic. Also provided here are methods of producing the animal model and methods of using such animal model.