The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2017
Filed:
Dec. 19, 2014
Applicants:
Timothy H. Bestor, New York, NY (US);
John R. Edwards, St. Louis, MO (US);
Jingyue Ju, Englewood Cliffs, NJ (US);
Xiaoxu LI, New York, NY (US);
Inventors:
Timothy H. Bestor, New York, NY (US);
John R. Edwards, St. Louis, MO (US);
Jingyue Ju, Englewood Cliffs, NJ (US);
Xiaoxu Li, New York, NY (US);
Assignee:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, New York, NY (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); C12P 19/34 (2006.01); C07H 19/23 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6806 (2013.01); C07H 19/23 (2013.01); C12Q 1/6827 (2013.01); C12Q 1/6874 (2013.01);
Abstract
This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransferase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to determine methylation patterns.