The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 22, 2017

Filed:

Dec. 23, 2013
Applicant:

Invista North America S.a R.l., Wilmington, DE (US);

Inventors:

Alex Van Eck Conradie, Eaglescliffe, GB;

Adriana Leonora Botes, Rosedale East, GB;

Changlin Chen, Ingleby Barwick, GB;

Paul S. Pearlman, Thornton, PA (US);

Assignee:

INVISTA NORTH AMERICA S.A.R.L., Wilmington, DE (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12P 7/40 (2006.01); C12P 7/18 (2006.01); C12P 7/42 (2006.01); C12P 7/44 (2006.01); C12P 13/00 (2006.01); C12P 7/24 (2006.01); C12N 9/04 (2006.01); C12N 15/52 (2006.01);
U.S. Cl.
CPC ...
C12P 7/40 (2013.01); C12N 9/0006 (2013.01); C12N 15/52 (2013.01); C12P 7/18 (2013.01); C12P 7/24 (2013.01); C12P 7/42 (2013.01); C12P 7/44 (2013.01); C12P 13/001 (2013.01); C12P 13/002 (2013.01);
Abstract

This document describes biochemical pathways for producing one or more of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C7 aliphatic backbone substrate produced from succinate semialdehyde or pyruvate. These pathways, metabolic engineering and cultivation strategies described herein rely on the aldol condensation of succinate semialdehyde and pyruvate.


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