The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2017
Filed:
May. 11, 2012
Applicants:
Koji Eto, Kyoto, JP;
Hiromitsu Nakauchi, Tokyo, JP;
Naoya Takayama, Kyoto, JP;
Sou Nakamura, Tokyo, JP;
Inventors:
Koji Eto, Kyoto, JP;
Hiromitsu Nakauchi, Tokyo, JP;
Naoya Takayama, Kyoto, JP;
Sou Nakamura, Tokyo, JP;
Assignee:
The University of Tokyo, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/078 (2010.01); C12N 15/85 (2006.01); A61K 35/19 (2015.01);
U.S. Cl.
CPC ...
C12N 15/85 (2013.01); A61K 35/19 (2013.01); C12N 5/0644 (2013.01); C12N 2501/165 (2013.01); C12N 2501/48 (2013.01); C12N 2506/02 (2013.01);
Abstract
An object of the present invention is to provide a method of promoting polyploidization of megakaryocytes and thereby producing highly polyploidized megakaryocytes, a method of efficiently producing platelets from polyploidized megakaryocytes, and the like. The present invention provides a method of producing polyploidized megakaryocytes comprising a step of forcing expression of an apoptosis suppressor gene in megakaryocytes before polyploidization and culturing the resulting cells.