The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 22, 2017

Filed:

Nov. 05, 2013
Applicants:

International Aids Vaccine Initiative, New York, NY (US);

Cornell University, Ithaca, NY (US);

The Scripps Research Institute, La Jolla, CA (US);

Inventors:

Michael Caulfield, Fort Washington, PA (US);

Albert Cupo, Stamford, CT (US);

Hansi Dean, New York, NY (US);

Simon Hoffenberg, Hartsdale, NY (US);

C. Richter King, Washington, DC (US);

P. J. Klasse, New York, NY (US);

Andre Marozsan, Milford, CT (US);

John P. Moore, New York, NY (US);

Rogier W. Sanders, New York, NY (US);

Andrew Ward, San Diego, CA (US);

Ian Wilson, La Jolla, CA (US);

Jean-Philippe Julien, San Diego, CA (US);

Assignees:

INTERNATIONAL AIDS VACCINE INITIATIVE, New York, NY (US);

THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA (US);

CORNELL UNIVERSITY, Ithaca, NY (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/21 (2006.01); C07K 14/005 (2006.01); A61K 39/39 (2006.01); A61K 39/12 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 39/12 (2013.01); A61K 39/21 (2013.01); A61K 39/39 (2013.01); C12N 2740/16034 (2013.01); C12N 2740/16122 (2013.01);
Abstract

The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization, electron microscopy and other biophysical, biochemical and immunological studies for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions, which are formulated into the vaccines of the present invention.


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