The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 22, 2017

Filed:

Mar. 25, 2014
Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Donald J. P. Pinto, Pennington, NJ (US);

Charles G. Clarke, Cherry Hill, NJ (US);

Leon M. Smith, II, Somerset, NJ (US);

Michael J. Orwat, New Hope, PA (US);

Yoon Jeon, Belle Mead, NJ (US);

James R. Corte, Yardley, PA (US);

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/00 (2006.01); C07D 491/107 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 401/06 (2006.01); C07D 413/04 (2006.01); C07D 413/06 (2006.01); C07D 417/14 (2006.01); C07D 471/10 (2006.01); C07D 487/04 (2006.01); C07D 491/10 (2006.01);
U.S. Cl.
CPC ...
C07D 491/107 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 413/04 (2013.01); C07D 413/06 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/10 (2013.01); C07D 487/04 (2013.01); C07D 491/10 (2013.01);
Abstract

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.


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