The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2017
Filed:
Aug. 06, 2013
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/02 (2006.01); C07D 407/02 (2006.01); C07D 405/14 (2006.01); C07D 401/06 (2006.01); C07C 225/16 (2006.01); C07D 213/74 (2006.01); C07D 213/89 (2006.01); C07D 231/12 (2006.01); C07D 233/60 (2006.01); C07D 471/06 (2006.01); C07D 277/64 (2006.01); C07F 5/02 (2006.01); C07C 49/248 (2006.01); C07C 49/252 (2006.01); C07C 225/22 (2006.01);
U.S. Cl.
CPC ...
C07D 401/06 (2013.01); C07C 49/248 (2013.01); C07C 49/252 (2013.01); C07C 225/16 (2013.01); C07C 225/22 (2013.01); C07D 213/74 (2013.01); C07D 213/89 (2013.01); C07D 231/12 (2013.01); C07D 233/60 (2013.01); C07D 277/64 (2013.01); C07D 405/14 (2013.01); C07D 471/06 (2013.01); C07F 5/022 (2013.01);
Abstract
Provided herein are curcumin analogues that are able to interact with amyloid β (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds in the treatment of Alzheimer's Disease or a related disorder.