The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2017
Filed:
Sep. 24, 2013
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
The Broad Institute, Inc., Cambridge, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Benjamin Vincent, Cambridge, MA (US);
Luke Whitesell, Somerville, MA (US);
Susan L. Lindquist, Cambridge, MA (US);
Willmen Youngsaye, Cumberland, RI (US);
Stephen L. Buchwald, Newton, MA (US);
Jean-Baptiste Langlois, Cambridge, MA (US);
Partha P. Nag, Somerville, MA (US);
Amal Ting, Newton, MA (US);
Barbara J. Morgan, Mayfield Heights, OH (US);
Benito Munoz, Newtonville, MA (US);
Sivaraman Dandapani, Malden, MA (US);
Bruce Tidor, Lexington, MA (US);
Raja R. Srinivas, Cambridge, MA (US);
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
The Broad Institute, Inc., Cambridge, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The present invention provides novel compounds (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits comprising the inventive compounds, or compositions thereof, for treating and/or preventing a fungal or protozoan infection, inhibiting the activity of a fungal or protozoan enzyme, killing a fungus or protozoon, or inhibiting the growth of a fungus or protozoon. The fungus may be aspecies,species, or other pathogenic fungal species. The compounds of the invention may inhibit the activity of fungal or protozoan cytochrome b and/or fungal or protozoan Hsp90. The present invention also provides synthetic methods of the inventive compounds.