The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2017
Filed:
Dec. 18, 2015
Applicant:
Wyeth Llc, New York, NY (US);
Inventors:
George Anello Chiarello, Morrisonville, NY (US);
Ayman Sahli, Amman, JO;
Assignee:
Wyeth LLC, Madison, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 319/20 (2006.01); A61K 47/48 (2006.01); C07C 241/04 (2006.01); C07C 319/12 (2006.01);
U.S. Cl.
CPC ...
C07C 319/20 (2013.01); A61K 47/48715 (2013.01); C07C 241/04 (2013.01); C07C 319/12 (2013.01);
Abstract
A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.