The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2017
Filed:
Mar. 15, 2013
Applicant:
Yale University, New Haven, CT (US);
Inventors:
Tarek M. Fahmy, New Haven, CT (US);
Lisa D. Pfefferle, Branford, CT (US);
Gary L. Haller, Hamden, CT (US);
Assignee:
Yale University, New Haven, CT (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/385 (2006.01); C12N 5/071 (2010.01); C12P 21/08 (2006.01); C07K 16/00 (2006.01); A61K 39/00 (2006.01); A61K 39/39 (2006.01); A61K 35/17 (2015.01);
U.S. Cl.
CPC ...
A61K 39/00 (2013.01); A61K 35/17 (2013.01); A61K 39/0011 (2013.01); A61K 39/385 (2013.01); A61K 39/39 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/6093 (2013.01);
Abstract
Carbon nanotube (CNT)-based compositions for activating cellular immune responses are provided. The CNTs function as high surface area scaffolds for the attachment of T cell ligands and/or antigens. The CNT compositions function as artificial antigen-presenting cells (aAPCs) or as modular vaccines. The disclosed CNT aAPCs are efficient at activating T cells and may be used to activate T cells ex vivo or in vivo for adoptive or active immunotherapy.