The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 2017
Filed:
Aug. 09, 2014
The Regents of the University of California, Oakland, CA (US);
Rommie E. Amaro, San Clemente, CA (US);
Roberta Baronio, Oxford, GB;
Ozlem Demir, San Diego, CA (US);
Peter Kaiser, Irvine, CA (US);
Richard H. Lathrop, Irvine, CA (US);
Seyedey-Faezeh Salehi-Amin, Pasadena, CA (US);
Christopher D. Wassman, San Francisco, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
A method of enhancing p53 activity of a p53 mutant polypeptide is provided. The method includes interacting a compound to an open L1/S3 binding site of the p53 mutant polypeptide, where the p53 activity of the p53 mutant polypeptide is enhanced in the presence of the compound. Compounds were identified from databases of compounds for virtual drug screening. Methods of screening for compounds that enhance p53 activity by binding to the open L1/S3 binding site, and methods of treatment using the identified compounds, are also provided.