The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 22, 2017

Filed:

Feb. 25, 2014
Applicant:

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Rajat Mittal, Vienna, VA (US);

Albert C. Lardo, Baldwin, MD (US);

Jung Hee Seo, Baltimore, MD (US);

Assignee:

The Johns Hopkins University, Baltimore, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/05 (2006.01); A61B 6/00 (2006.01); A61B 6/03 (2006.01); A61B 5/02 (2006.01); A61B 5/00 (2006.01); A61B 5/026 (2006.01); G06T 7/00 (2017.01);
U.S. Cl.
CPC ...
A61B 6/507 (2013.01); A61B 5/0044 (2013.01); A61B 5/026 (2013.01); A61B 5/02007 (2013.01); A61B 6/03 (2013.01); A61B 6/032 (2013.01); A61B 6/481 (2013.01); A61B 6/503 (2013.01); A61B 6/504 (2013.01); A61B 6/5205 (2013.01); A61B 6/5217 (2013.01); G06T 7/0016 (2013.01); F04C 2270/041 (2013.01); G06T 2207/10076 (2013.01); G06T 2207/10081 (2013.01); G06T 2207/30076 (2013.01); G06T 2207/30104 (2013.01);
Abstract

An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transluminal attenuation gradient for the coronary artery of the patient. The patient specific transluminal attenuation gradient is used to determine an estimate of a coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and/or fractional flow reserve for the patient. Coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and fractional flow reserve can then be used to estimate the functional severity of coronary artery stenosis.


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